Principal Scientist, Medicinal Chemistry in South San Francisco, CA at Johnson Service Group

Date Posted: 1/14/2022

Job Snapshot

Job Description

JobID: 388529

Johnson Service Group is looking for a Principal Scientist, Medicinal Chemistry for one of our Client’s. 

Candidate will be an experienced medicinal chemist with a proven industry drug discovery track record to play a leadership role at research site. Client focuses on drug discovery research services across a variety of disciplines including small-molecule chemistry support, PKDM services, in vitro and in vivo biology, contract manufacturing and discovery biologics.

The successful candidate should have a demonstrated record of achievement in medicinal chemistry, exhibited by publications, patents and/or IND-filings, and a deep understanding of both synthetic organic methodology and medicinal chemistry. Additionally, the ideal candidate will be a dynamic individual capable of managing relationships with our clients and our-China based colleagues. Experience leading research programs in small molecule lead discovery and optimization is critical, and the ability to manage chemistry and project teams located primarily in China is necessary.  English fluency is required, and Mandarin fluency is preferred but not required.


  • Small-molecule drug discovery project leadership that integrates client objectives with full use of Client resources.
  • Flexibility to support programs that require project management across functions and that may occasionally necessitate contributions “from the bench” with laboratory-based research.
  • Broad capability in designing small-molecule drug candidates based on in vitro and in vivo biological activity, PKDM, physicochemical and IP-relevant data.
  • Understanding of current synthetic methods, traditional medicinal chemistry principles, general target biology, structure-based drug design and IP concerns related to small molecule drug discovery.
  • Effective communication with the client as well as the project team members located in China.


  • Ph.D. in organic or medicinal chemistry with > 8 years industrial experience for Principal Scientist.
  • Record of achievement in drug discovery by published peer-reviewed journals, patent applications and/or IND-filings.
  • Experience leading chemistry teams on small-molecule drug discovery projects.
  • Demonstrated expertise in structure-based drug design that includes familiarity with computational tools commonly used in the field.
  • Drive to be a defining and indispensable member of an evolving, industry-leading team that sets the standard for innovation partners worldwide.


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